LAB687

Overview

LAB687 is a microsomal triglyceride transfer protein ( MTP ) inhibitor with an IC 50 of 0.9 nM for apolipoprotein B ( apoB ) secretion in HepG2 cells. LAB687 also acts as a Smoothened ( Smo ) antagonist, with IC 50 values of 2.48 μM and 3.42 μM against mouse and human Smo receptors, respectively. LAB687 reduces triglyceride and low-density lipoprotein cholesterol ( LDL-C ) levels, and inhibits the Hedgehog signaling pathway. LAB687 can be used in studies related to Hedgehog-dependent cancers.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Microsomal Triglyceride Transfer Protein (MTP) | Products > Signaling Pathways > Smo | Products > Signaling Pathways > Hedgehog | Products > Signaling Pathways > LDLR

Product Information

• Catalog No.: HY-177291
• CAS No.: 256397-11-2
• Molecular Formula: C26H23F3N2O3
• Molecular Weight: 468.47
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source