SV119 hydrochloride

Overview

SV119 hydrochloride is a sigma-2 ligand with a K i value of 5.2 nM. SV119 hydrochloride enhances the efficient transport of drugs across the plasma membrane of cancer cells. The conjugation of dm-Erastin with SV119 hydrochloride successfully overcomes the internalization barrier observed in pancreatic cancer , while preserving the inherent anti-tumor activity of Erastin ( HY-15763 ). Additionally, SV119 hydrochloride demonstrates cytotoxic effects on triple-negative breast cancer (TNBC) cells and induces apoptosis .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Triple-Negative Breast Cancer | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > Sigma Receptor | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-177345A
• CAS No.: 913816-12-3
• Molecular Formula: C23H39Cl2N3O3
• Molecular Weight: 476.48
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source