MSC778

Overview

MSC778 is an effective and orally active flap endonuclease 1 ( FEN1 ) inhibitor with an IC 50 of 3 nM and a K D of 2.9 nM. MSC778 exhibits 145-fold, 516-fold, and 65-fold selectivity over EXO1, GEN1, and XPG, respectively. MSC778 selectively kills BRCA2-deficient cells and potentiates the activity of Niraparib ( HY-10619 ) to induce tumor stasis in a BRCA2 KO DLD-1 mouse xenograft. MSC778 can be used in the research of colorectal cancer .

Application

Products | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > FLAP

Product Information

• Catalog No.: HY-177512
• CAS No.: 3098173-17-9
• Molecular Formula: C22H20ClN3O5
• Molecular Weight: 441.86
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source