STAT3-IN-52 is an orally active STAT3 inhibitor with a K i value of 2.42 μM. STAT3-IN-52 binds directly and selectively to the pY705 site of STAT3 ( K i = 0.44 μM), thereby impairing its function. STAT3-IN-52 induces apoptosis and triggers anti-tumor responses in vivo. STAT3-IN-52 can be used in breast cancer-related research.
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