D574-0246

Overview

D574-0246 is a dual-activity inhibitor of OXCT1 , inhibiting both the ketolytic and succinyltransferase activities of OXCT1 . D574-0246 reduces substrate-specific (LACTB K284) and global protein succinylation and decreases OXCT1 ketolytic activity in HepG2 cells. D574-0246 inhibits the viability of HCC cells ( IC 50 : 16.49 μM in PLC cells, 6.656 μM in HepG2 cells). D574-0246 exerts anti-tumor efficacy in nude mice bearing OXCT1 -overexpressing HepG2 xenograft tumors. D574-0246 can be used for the study of hepatocellular carcinoma (HCC).

Application

Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Mitochondrial Metabolism

Product Information

• Catalog No.: HY-178018
• CAS No.: 1269110-12-4
• Molecular Formula: C24H26N6O3
• Molecular Weight: 446.50
• Purity: 99.95%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (11.20 mM); Clear solution
• Availability: In-stock

Source

Original product source