PRMT5-IN-53

Overview

PRMT5-IN-53 is a gut-restricted and orally active PRMT5 inhibitor with pIC 50 s of ≥ 9.7 against hPRMT5 and mPRMT5 . PRMT5-IN-53 binds to the PRMT5:MEP50 complex with a K D of 11.3 pM. PRMT5-IN-53 effectively inhibits PRMT5 locally in the intestines of mice, significantly reducing the number and area of polyps, while avoiding systemic hematological toxicity (such as anemia, neutropenia). PRMT5-IN-53 can be used for the study of colorectal cancer especially for familial adenomatous polyposis ( FAP ).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Histone Methyltransferase

Product Information

• Catalog No.: HY-178028
• CAS No.: 3113303-04-8
• Molecular Formula: C21H22N6O2
• Molecular Weight: 390.44
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source