GSTO1-IN-4 is a selective, potent GSTO1-1 inhibitor ( IC 50 = 0.04 μM; K I = 0.16 μM). GSTO1-IN-4 shows low inhibition to GSTO2-2, GSTA1-1 and GSTP1-1. GSTO1-IN-4 shows a capacity to attenuate inflammation in mice and to significantly enhance the cytotoxicity of Cisplatin ( HY-17394 ). GSTO1-IN-4 can be used for the study of inflammation and breast cancer .
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