METTL3-IN-11

Overview

METTL3-IN-11 is an excellent, selective METTL3 inhibitor ( IC 50 = 45.31 nM). METTL3-IN-11 exhibits high selectivity towards METTL3 compared to DNMT1 , EZH1 , MLL1, and PRMT1 . METTL3-IN-11 reduces the m6A level of total RNA in MOLM-13 and SKOV3 cells, induces cell apoptosis , and inhibits cell migration. METTL3-IN-11 can reduce the expression of m6A downstream target genes ( c-MYC and BCL2 ). METTL3-IN-11 can be used for the study of ovarian cancer and acute myeloid leukemia.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > METTL3 | Products > Signaling Pathways > c-Myc | Products > Signaling Pathways > Bcl-2 Family

Product Information

• Catalog No.: HY-178446
• CAS No.: 3069369-05-4
• Molecular Formula: C26H28N6O3
• Molecular Weight: 472.54
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source