SJY26

Overview

SJY26 is a PI3K/HDAC dual-target inhibitor with IC 50 s of 0.59 nM ( PI3Kα and PI3Kδ ), 2.02 nM ( PI3Kγ ), 12.69 nM ( PI3Kβ ) and 114 nM ( HDAC1 ). SJY26 exhibits potent broad-spectrum anti-proliferative activity, and is particularly sensitive to Jurkat and PC9R cells. SJY26 inhibited the migration of PC9R cells, arrested the cell cycle and induced cell apoptosis . SJY26 reduces AKT phosphorylation, and decreases histone H3 deacetylation ( Ac-H3 ). SJY26 can be used for the studies of non-small cell lung cancer and leukemia.

Application

Products | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > HDAC | Products > Signaling Pathways > Akt | Products > Signaling Pathways > Histone Methyltransferase

Product Information

• Catalog No.: HY-178485
• CAS No.: 3106582-33-3
• Molecular Formula: C35H26F2N6O5S
• Molecular Weight: 680.68
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source