Wee1/HDAC-IN-1

Overview

Wee1/HDAC-IN-1 is a dual Wee1/HDAC inhibitor with an IC 50 of 1.2 nM for Wee1 and IC 50 values of 196 nM for HDAC1 , 156 nM for HDAC3 , and 55 nM for HDAC6 . Wee1/HDAC-IN-1 exhibits strong antiproliferative activity against MV4-11 cells with an IC 50 of 0.076 μM. Wee1/HDAC-IN-1 selectively binds to Wee1 and HDACs . Wee1/HDAC-IN-1 interferes with DNA damage repair pathways and induces apoptosis in MV4-11 cells. Wee1/HDAC-IN-1 Wee1/HDAC-IN-1 can be used for the research of acute myeloid leukemia (AML).

Application

Products | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Acute Myeloid Leukemia | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Wee1 | Products > Signaling Pathways > HDAC | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-179272
• CAS No.: 3037071-29-4
• Molecular Formula: C33H43N9O4
• Molecular Weight: 629.75
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source