CC-M-1 is a potent and selective PI3K/mTOR inhibitor. CC-M-1 inhibits PI3Kα/β/γ/δ and mTOR with IC 50 values of 0.68, 1.02, 1.03, 8.03, and 15 nM, respectively. CC-M-1 inhibits the proliferation of colorectal cancer cell lines, including HCT-116 ( IC 50 = 0.38 μM) and HT-29 ( IC 50 = 1.70 μM). CC-M-1 can be used for colorectal cancer (CRC) research.
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