SY-5102

Overview

SY-5102 is a potent, selective and orally active cyclin-dependent kinase ( CDK7 ) inhibitor with a K d of 0.03 nM. SY-5102 shows anti-proliferative activity against HCC70 cells with an EC 50 of 9 nM. SY-5102 can inhibit CDK7-mediated CAK function (downregulate CDK2 Thr160 phosphorylation) and TFIIH transcription function (downregulate RNA polymerase II Ser5 phosphorylation). SY-5102 can induce G2/M cell cycle arrest, downregulate the expression of the oncogene c-Myc , and ultimately trigger cancer cell apoptosis . SY-5102 can be used for the research of triple-negative breast cancer (TNBC).

Application

Products | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Triple-Negative Breast Cancer | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Ser/Thr Kinase | Products > Signaling Pathways > c-Myc | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-180355
• CAS No.: 2365230-48-2
• Molecular Formula: C22H22F3N7O
• Molecular Weight: 457.45
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source