HK2-IN-3

Overview

HK2-IN-3 (compound 12) is a potent hexokinase 2 ( HK2 ) inhibitor with an IC 50 of 56.4 nM. HK2-IN-3 reduces glucose uptake and downregulated GLUT1/GLUT4 in oral squamous cell carcinoma (OSCC). HK2-IN-3 induces mitophagy and apoptosis . HK2-IN-3 suppresses tumor growth and angiogenesis in OSCC xenograft mouse models. HK2-IN-3 can be used for OSCC research.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Melanoma | Products > Disease Areas > Squamous Cell Carcinoma | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Hexokinase | Products > Signaling Pathways > Mitophagy | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > GLUT

Product Information

• Catalog No.: HY-180805
• CAS No.: 2679261-30-2
• Molecular Formula: C15H11N3O4S
• Molecular Weight: 329.33
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source