YCH3292

Overview

YCH3292, a derivative of YCH189 ( HY-155993 ) is a potent, selective and orally active PARP1/2 inhibitor with IC 50 both <0.001 nM. YCH3292 can increase the stability of PARP-DNA complexes. YCH3292 exhibits robust antiproliferative activity. YCH3292 can induce double-strand breaks in DNA, increase the protein levels of γH2AX , P-RPA32 , and P-Chk1 and induce tumor cells S or G2/M phase arrest and apoptosis . YCH3292 can inhibit tumor growth in MC38 xenograft model.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > PARP

Product Information

• Catalog No.: HY-180809
• CAS No.: 3049753-10-5
• Molecular Formula: C28H23FN6O3
• Molecular Weight: 510.52
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source