CDK2-IN-55

Overview

CDK2-IN-55 (Compound 12c) is a CDK2 inhibitor with an IC 50 value of 4.7 nM. CDK2-IN-55 also has a strong inhibitory effect on CDK1 ( IC 50 = 26.3 nM), moderate inhibitory effects on Aurora A ( IC 50 = 92.0 nM) and CDK9 ( IC 50 = 288 nM), and very weak inhibitory activities on CDK4 , CDK6 , DYRK1A, and GSK3β ( IC 50 > 1000 nM). CDK2-IN-55 shows strong anti-proliferative activity against various cancer cell lines, inducing cell cycle arrest and apoptosis . CDK2-IN-55 can be used for research on colorectal cancer , lung cancer , and cervical cancer .

Application

Products | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Cervical Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Respiratory Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Aurora Kinase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-180817
• CAS No.: 3099101-44-4
• Molecular Formula: C18H20N6O2S2
• Molecular Weight: 416.52
• Purity: 98.91%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source