Laduviglusib

Overview

Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC 50 s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy .

Application

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Product Information

• Catalog No.: HY-10182
• CAS No.: 252917-06-9
• Molecular Formula: C22H18Cl2N8
• Molecular Weight: 465.34
• Purity: 99.46%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
• Solubility: ≥ 2.08 mg/mL (4.47 mM); Clear solution
• Availability: In-stock

Source

Original product source