VARS1-IN-2 (Compound 2901) is a VARS1 inhibitor with a K d of 0.014 µM. VARS1-IN-2 does not alter VARS1 expression either at mRNA or protein level. VARS1-IN-2 exerts anti-prostate cancer effects mainly through interfering VARS1’s tRNA aminoacylation activity but not its expression.
Products | Products > Disease Areas > Cancer | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Urogenital Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Aminoacyl-tRNA Synthetase
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