Laduviglusib monohydrochloride

Overview

Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC 50 s of 10 nM and 6.7 nM. Laduviglusib monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib monohydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib monohydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib monohydrochloride induces autophagy .

Application

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Product Information

• Catalog No.: HY-10182A
• CAS No.: 1797989-42-4
• Molecular Formula: C22H19Cl3N8
• Molecular Weight: 501.80
• Purity: 99.93%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)
• Solubility: ≥ 2.08 mg/mL (4.15 mM); Clear solution
• Availability: In-stock

Source

Original product source