PTP1B-IN-33 is a PTP1B inhibitor with a human IC 50 of 2.45 μM and over 20-fold selectivity for PTP1B over SHP2 . PTP1B-IN-33 enhances π-Alkyl interaction with PTP1B to increase WPD loop closure degree. PTP1B-IN-33 can be used for the research of cancer , diabetes, autoimmune deficiency diseases.
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