WX-02-43

Overview

WX-02-43 is a weak covalent inhibitor of SF3B1 , and is the (1S,3R) enantiomer of WX-02-23 ( HY-168534 ). WX-02-43 cannot effectively covalently modify the C258 site in the DNA-binding domain of FOXA1 , and its inhibitory activity against SF3B1 is also weaker than that of WX-02-23 . WX-02-43 serves as a negative control probe that fails to remodel the chromatin binding pattern and transcriptional activity of FOXA1 . WX-02-43 can be used in studies on cancers such as prostate cancer to verify the specific effects of WX-02-23 on FOXA1 and SF3B1 targets.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Urogenital Cancer | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > SF3B1

Product Information

• Catalog No.: HY-181421
• CAS No.: 2929223-36-7
• Molecular Formula: C26H25N3O5
• Molecular Weight: 459.49
• Purity: 99.49%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.44 mM); Clear solution
• Availability: In-stock

Source

Original product source