Polθ-IN-10

Overview

Polθ-IN-10 is an orally active Polθ-pol inhibitor (with a human IC 50 of 1.3 nM) that exhibits oral bioavailability in mice and rats. Polθ-IN-10 binds to the allosteric site of Polθ-pol, disrupts the microhomology-mediated end-joining DNA repair pathway, and inhibits CYP2C9 ( IC 50 =1.63 μM). Polθ-IN-10 selectively inhibits the proliferation of HR-deficient cancer cells and induces apoptosis . Polθ-IN-10 is applicable to the research of HR-deficient cancers.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cytochrome P450

Product Information

• Catalog No.: HY-181611
• CAS No.: 3068829-46-6
• Molecular Formula: C27H24F4N6O3
• Molecular Weight: 556.51
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source