CHI3L1-IN-7 is a selective CHI3L1 inhibitor with a K d of 7.40 μM and an IC 50 of 15.4 μM. CHI3L1-IN-7 blocks CHI3L1's interaction with galectin-3 , inhibits STAT3 phosphorylation, reduces the viability of multicellular 3D glioblastoma spheroids. CHI3L1-IN-7 can be used for the research of glioblastoma and CHI3L1-mediated tumor immune regulation.
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