Atopaxar hydrochloride

Overview

Atopaxar hydrochloride (E5555 hydrochloride) is the hydrochloride salt form of Atopaxar ( HY-18200 ). Atopaxar hydrochloride is an orally active, selective and reversible antagonist for thrombin receptor protease-activated receptor-1 (PAR-1) . Atopaxar hydrochloride is the inhibitor for Janus kinase 1 ( JAK1 ) and JAK2 , which inhibits the JAK-STAT with EC 50 of 5.90 μM in A549. Atopaxar hydrochloride inhibits the cell viability of A549 ( IC 50 =7.02 μM), arrests the cell cycle at G1 phase and induces apoptosis . Atopaxar hydrochloride exhibits antiplatelet and antitumor activities. Atopaxar hydrochloride can be used for the research of atherothrombotic disease.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Protease Activated Receptor (PAR) | Products > Signaling Pathways > JAK

Product Information

• Catalog No.: HY-18200A
• CAS No.: 474544-83-7
• Molecular Formula: C29H39ClFN3O5
• Molecular Weight: 564.09
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source