UCI-1014

Overview

UCI-1014 is a mutant p53 ( p53 R175H ) corrector/reactivator. UCI-1014 restores the wild-type-like DNA-binding activity of p53 R175H , promotes the redistribution of the mutant protein to chromatin, and induces the expression of p53-dependent target genes. UCI-1014 inhibits the proliferation of p53 R175H -mutant cancer cells through an SLC7A11-independent mechanism. UCI-1014 can be used for research related to p53-mutant cancers.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Ovarian Cancer | Products > Disease Areas > Urogenital Cancer | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > MDM-2/p53

Product Information

• Catalog No.: HY-183622
• CAS No.: 304896-41-1
• Molecular Formula: C16H12N2O4
• Molecular Weight: 296.28
• Purity: 98.43%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source