AM9053

Overview

AM9053 is a selective, effective and slowly reversible inhibitor of N-acyl ethanolamine acid amidease ( NAAA ) ( IC 50 = 30 nM). The effect of AM9053 on FAAH activity is limited ( IC 50 > 100 nM). AM9053 inhibits the proliferation of colorectal cancer cells by activating the PPAR-α and TRPV1 dependent mechanisms and induces S-phase cell cycle arrest. AM9053 alleviates intestinal fibrosis by regulating macrophage activity and inhibiting the IL-23 signaling pathway. AM9053 leads to an increase in NAE levels, especially PEA and OEA. AM9053 can be used for the study of colorectal cancer and intestinal fibrosis.

Application

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Product Information

• Catalog No.: HY-185011
• CAS No.: 157469-21-1
• Molecular Formula: C17H25NS
• Molecular Weight: 275.45
• Purity: 99.98%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 5 mg/mL (18.15 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source