EphB4-IN-1

Overview

EphB4-IN-1 is a selective EphB4 tyrosine kinase inhibitor with IC 50 values of 0.16-0.30 μM. EphB4-IN-1 binds to the ATP binding site of EphB4 in a DFG-in conformation, forming four stable intermolecular hydrogen bonds. EphB4-IN-1 also inhibits Src , Abl1 , Lck , and EGFR kinases. EphB4-IN-1 inhibits EphB4 autophosphorylation. EphB4-IN-1 can be used for the research of cancer , such as non small cell lung cancer .

Application

Products | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Respiratory Disease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Ephrin Receptor | Products > Signaling Pathways > Src | Products > Signaling Pathways > Bcr-Abl | Products > Signaling Pathways > EGFR

Product Information

• Catalog No.: HY-185227
• CAS No.: 1394837-94-5
• Molecular Formula: C18H18N4O2
• Molecular Weight: 322.36
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source