ML346

Overview

ML346 is an activator of Hsp70 expression and HSF-1 activity , with an EC 50 of 4.6 μM for Hsp70 . ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70 , Hsp40 , and Hsp27.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > HSP

Product Information

• Catalog No.: HY-18669
• CAS No.: 100872-83-1
• Molecular Formula: C14H12N2O4
• Molecular Weight: 272.26
• Purity: 98.25%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 1.25 mg/mL (4.59 mM); Clear solution
• Availability: In-stock

Source

Original product source