AMG-337

Overview

AMG-337 is a potent, orally active, selective MET kinase inhibitor with IC 50 values of 1, 1, 4.7, 5, 21.5, 1077 and >4000 nM of WT MET, H1094R MET, M1250T MET, HGF-stimulated pMET (PC3 cells) MET, V1092I MET, Y1230H MET, and D1228H MET, respectively. AMG 337 inhibits the phosphorylation of MET and downstream effectors in MET-amplified cancer cell lines, resulting in an inhibition of MET-dependent cell proliferation and induction of apoptosis .

Application

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Product Information

• Catalog No.: HY-18696
• CAS No.: 1173699-31-4
• Molecular Formula: C23H22FN7O3
• Molecular Weight: 463.46
• Purity: 99.40%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (5.39 mM); Clear solution
• Availability: In-stock

Source

Original product source