SCR-1481B1

Overview

SCR-1481B1 (Metatinib anhydrous; c-Met inhibitor 2) is an inhibitor of the N-terminal fragment of Gasdermin D (GSDMD) , with an IC 50 of 1.04 μM and a K a of 0.42 μM in mice. SCR-1481B1 effectively blocks GSDMD-NT oligomerization and pore formation, inhibits GSDMD-mediated pyroptosis ( Pyroptosis ), preserves mitochondrial integrity, and reduces proinflammatory cytokine secretion. SCR-1481B1 also inhibits angiogenesis, exerts GSDMD-independent antitumor effects, and enhances the infiltration of antitumor immune cells. SCR-1481B1 is also an inhibitor targeting to c-MET and VEGFR2 , can be used in studies related to melanoma and sepsis.

Application

Products | Products > Disease Areas > Melanoma | Products > Disease Areas > Metastatic Melanoma | Products > Disease Areas > Cancer | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > Pyroptosis | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > c-Met/HGFR | Products > Signaling Pathways > VEGFR

Product Information

• Catalog No.: HY-18711A
• CAS No.: 1174161-86-4
• Molecular Formula: C32H40ClF2N6O13P
• Molecular Weight: 821.12
• Purity: 99.95%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (3.04 mM); Clear solution
• Availability: In-stock

Source

Original product source