L-NAME inhibits NOS with an IC 50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC 50 value of 1.4 μM. L-NAME requires hydrolysis of the methyl ester by cellular esterases to become a fully functional inhibitor. L-NAME can be used to induce hypertension and preeclampsia models.
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