Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate), a phorbol ester, is a dual SphK and protein kinase C ( PKC ) activator. Phorbol 12-myristate 13-acetate is a NF-κB activator . Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells ( Validated by MedChemExpress ).
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