SB-267268

Overview

SB-267268 is a selective and nonpeptidic alpha(v)beta3 ( αvβ3 ) and alpha(v)beta5 ( αvβ5 ) integrins antagonist, with K i s of 0.9, 0.5 and 0.7 nM for human αvβ3 , monkey αvβ3 and human αvβ5 , respectively. SB-267268 inhibits human and mouse αvβ3 with IC 50 s of 0.68 and 0.29 nM, respectively. SB-267268 reduces angiogenesis and VEGF expression.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Obesity | Products > Signaling Pathways > Cytoskeleton | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Integrin

Product Information

• Catalog No.: HY-19306
• CAS No.: 205678-26-8
• Molecular Formula: C22H24F3N3O4
• Molecular Weight: 451.44
• Purity: 99.85%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source