PIM-447 dihydrochloride

Overview

PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan- PIM kinase inhibitor, with K i values of 6, 18, and 9 pM for PIM1 , PIM2 , and PIM3 , respectively. PIM447 dihydrochloride displays dual antimyeloma and bone-protective effects. PIM447 dihydrochloride induces apoptosis .

Application

Products | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Obesity | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Pim | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-19322B
• CAS No.: 1820565-69-2
• Molecular Formula: C24H25Cl2F3N4O
• Molecular Weight: 513.38
• Purity: 99.82%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (4.87 mM); Clear solution
• Availability: In-stock

Source

Original product source