Branaplam

Overview

Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC 50 of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC 50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.

Application

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Product Information

• Catalog No.: HY-19620
• CAS No.: 1562338-42-4
• Molecular Formula: C22H27N5O2
• Molecular Weight: 393.48
• Purity: 98.90%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
• Solubility: ≥ 2.08 mg/mL (5.29 mM); Clear solution
• Availability: In-stock

Source

Original product source