3PO is an inhibitor of PFKFB3 . 3PO attenuates the proliferation of several cancer cell lines with IC 50 s of 1.4-24 μmol/L. 3PO suppresses glucose uptake and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD + and NADH. 3PO can be used for the research of cancer .
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