GS-9667

Overview

GS-9667 (CVT 3619), a novel N 6 -5'-substituted adenosine analog, is a selective, partial agonist of the A 1 adenosine receptor (A 1 AdoR) . GS-9667 binds to adipocyte membranes with high (K H =14 nM) and low (K L =5.4 μM) affinities. GS-9667 reduces cyclic AMP content and release of nonesterified fatty acids from epididymal adipocytes with IC 50 values of 6 nM and 44 nM, respectively. GS-9667 inhibits lipolysis and has the potential for Type 2 diabetes (T2DM) and dyslipidemia via lowering of free fatty acids (FFA).

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Glucose Metabolism | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Adenosine Receptor

Product Information

• Catalog No.: HY-19842
• CAS No.: 618380-90-8
• Molecular Formula: C21H24FN5O4S
• Molecular Weight: 461.51
• Purity: 98.08%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source