RN-1734

Overview

RN-1734 is selective antagonist of the TRPV4 channel , completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC 50 s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM). RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells.

Application

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Product Information

• Catalog No.: HY-19975
• CAS No.: 946387-07-1
• Molecular Formula: C14H22Cl2N2O2S
• Molecular Weight: 353.31
• Purity: 99.75%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 3.25 mg/mL (9.20 mM); Clear solution
• Availability: In-stock

Source

Original product source