Tesirine intermediate-2

Overview

Tesirine intermediate-2 is the intermediate of Tesirine ( HY-128952 ). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs) , the warhead component of the payload is SG3199 ( HY-101161 ), which has strong anticancer cell activity.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > DNA Alkylator/Crosslinker

Product Information

• Catalog No.: HY-24144
• CAS No.: 1430738-34-3
• Molecular Formula: C40H55N5O10Si
• Molecular Weight: 793.98
• Purity: 99.43%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (6.30 mM); Clear solution
• Availability: In-stock

Source

Original product source