TETi76

Overview

TETi76 is an orally active TET family inhibitor with IC 50 values ??of 1.5, 9.4 and 8.8 μM for TET1 , TET2 and TET3 , respectively. TETi76 competitively binds to the active site of TET enzymes , reduces cytosine hydroxymethylation and restricts clonal growth of TET2 mutants in vitro and in vivo, but does not affect the growth of normal hematopoietic precursor cells. TETi76 can be used for leukemia research.

Application

Products | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > TET Protein

Product Information

• Catalog No.: HY-402410
• CAS No.: 1451750-73-4
• Molecular Formula: C10H16O5
• Molecular Weight: 216.23
• Purity: 97.49%
• Storage: 4°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (11.56 mM); Clear solution
• Availability: In-stock

Source

Original product source