DYRK2-IN-2

Overview

DYRK2-IN-2 (Compound C17) is a selective inhibitor of DYRK2 , with its IC 50 value being 40.3 nM. The inhibitory activity of DYRK2-IN-2 on DYRK1A ( IC 50 = 1842 nM), DYRK1B ( IC 50 = 1335 nM), DYRK4 ( IC 50 = 1931 nM), DYRK3 ( IC 50 = 112 nM), and CLKs ( IC 50 = 540-6496 NM) is relatively low. DYRK2-IN-2 inhibits the phosphorylation of Tau protein at Thr212 and shows moderate cytotoxicity in HT22 cells. DYRK2-IN-2 can be used in cancer research.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > DYRK | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Tau Protein

Product Information

• Catalog No.: HY-402805
• CAS No.: 2416195-65-6
• Molecular Formula: C21H24N2O3S
• Molecular Weight: 384.49
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source