Tesirine intermediate-1

Overview

Tesirine intermediate-1 is the intermediate of Tesirine ( HY-128952 ). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs) , the warhead component of the payload is SG3199 ( HY-101161 ), which has strong anticancer cell activity.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > DNA Alkylator/Crosslinker

Product Information

• Catalog No.: HY-47820
• CAS No.: 1430738-05-8
• Molecular Formula: C28H48N2O7Si2
• Molecular Weight: 580.86
• Purity: 99.41%
• Storage: -20°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Availability: In-stock

Source

Original product source