MK-2461

Overview

MK-2461 is an ATP-competitive, selective and orally active wild-type and mutant c-Met inhibitor ( IC 50 s: 0.4-2.5 nM). MK-2461 also inhibits Ron (IC 50 of 7 nM) and Flt1 (IC 50 of 10 nM), MK-2461 shows selective for c-MET over other kinases (lC 50 s = 22-7800 nM). MK-2461 can be used for the study of cancer , such as gastric cancer .

Application

Products | Products > Disease Areas > Gastric Cancer | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Ovarian Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > c-Met/HGFR

Product Information

• Catalog No.: HY-50703
• CAS No.: 917879-39-1
• Molecular Formula: C24H25N5O5S
• Molecular Weight: 495.55
• Purity: 99.28%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (5.04 mM); Clear solution
• Availability: In-stock

Source

Original product source