Linifanib

Overview

Linifanib (ABT-869) is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC 50 s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ , and FLT3 , respectively. Linifanib shows prominent antitumor activity. Linifanib has much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. Linifanib is a specific miR-10b inhibitor that blocks miR-10b biogenesis.

Application

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Product Information

• Catalog No.: HY-50751
• CAS No.: 796967-16-3
• Molecular Formula: C21H18FN5O
• Molecular Weight: 375.40
• Purity: 99.39%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
• Solubility: ≥ 1.32 mg/mL (3.52 mM); Clear solution
• Availability: In-stock

Source

Original product source