ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC 50 of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM.
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