Tizanidine hydrochloride

Overview

Tizanidine hydrochloride, a skeletal muscle relaxant, is an orally effective central α 2 -adrenoceptor agonist ( IC 50 = 6.9 nmol). Tizanidine hydrochloride primarily exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons. Tizanidine hydrochloride has anti-injury activity and can inhibit gastrointestinal (GI) transport. Tizanidine hydrochloride can inhibit the proliferation, migration, and invasion of lung cancer cells and induce cell apoptosis by upregulating Nischarin and inhibiting the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine hydrochloride can be used to treat spasticity caused by diseases such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI).

Application

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Product Information

• Catalog No.: HY-B0194A
• CAS No.: 64461-82-1
• Molecular Formula: C9H9Cl2N5S
• Molecular Weight: 290.17
• Purity: 99.93%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 5 mg/mL (17.23 mM); Clear solution
• Availability: In-stock

Source

Original product source