(R)-Afatinib

Overview

(R)-Afatinib ((R)-BIBW 2992) is the Afatinib isomer. Afatinib ( HY-10261 ) is an orally active, potent and irreversible dual specificity inhibitor of?ErbB?family ( EGFR ?and? HER2 ), with?IC 50 ?values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for?EGFR wt , EGFR L858R ,?EGFR L858R/T790M ?and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung?cancer?(NSCLC) and gastric?cancer.

Application

Products | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > c-Met/HGFR | Products > Signaling Pathways > p38 MAPK

Product Information

• Catalog No.: HY-10261E
• CAS No.: 439081-17-1
• Molecular Formula: C24H25ClFN5O3
• Molecular Weight: 485.94
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source