Chlorpromazine hydrochloride

Overview

Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT 2A , which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase ( CcO ), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNa v 1.7 channels ( IC 50 =25.9 μM; concentration-dependent) and HERG potassium channels ( IC 50 =21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis.

Application

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Product Information

• Catalog No.: HY-B0407A
• CAS No.: 69-09-0
• Molecular Formula: C17H20Cl2N2S
• Molecular Weight: 355.33
• Purity: 99.82%
• Storage: 4°C, sealed storage, away from moisture and light * The compound is unstable in solutions, freshly prepared is recommended.
• Solubility: ≥ 200 mg/mL (562.86 mM); Clear solution
• Availability: In-stock

Source

Original product source