Chelerythrine

Overview

Chelerythrine is a benzophenanthridine alkaloid extracted from the plant Greater celandine (Chelidonium majus). It is a potent, selective, and cell-permeable protein kinase C inhibitor. It is also the major active natural product found in the plant Zanthoxylum clava-herculis, exhibiting anti-bacterial activity against Staphylococcus aureus. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | Bcl-2 Family

Product Information

• Catalog No.: B0084-190109
• CAS No.: 34316-15-9
• Molecular Formula: C21H18NO4+
• Molecular Weight: 348.37
• Purity: 98%
• Storage: Store at -20°C
• Solubility: Soluble in Chloroform (Slightly, Sonicated), DMSO (Slightly, Sonicated), Methanol (Slightly)

Source

Original product source