Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase ( MAO-A and MAO-B ) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO) , and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 ( Ki : 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .
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