Aceglutamide

Overview

Aceglutamide (α-N-Acetyl-L-glutamine; N2-Acetylglutamine) is a neuroprotectant that can penetrate the blood-brain barrier. Aceglutamide can enhance the antioxidant systems of glutathione (GSH), thioredoxin ( Trx ) and Nrf2 . Aceglutamide also inhibits ASK1 and TRAF1 , activates the Akt/Bcl-2 anti-apoptotic pathway, enhances the activity of antioxidant enzymes and reduces oxidative damage. Aceglutamide can improve neurological deficits after cerebral ischemia, reduce infarct volume, and inhibit neuronal apoptosis , especially substantia nigra dopaminergic neurons. Aceglutamide can reduce cerebral ischemia/reperfusion injury, improve motor dysfunction, and is used in ischemic stroke-related research.

Application

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Product Information

• Catalog No.: HY-B1065
• CAS No.: 2490-97-3
• Molecular Formula: C7H12N2O4
• Molecular Weight: 188.18
• Purity: 98.0%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 1.67 mg/mL (8.87 mM); Clear solution
• Availability: In-stock

Source

Original product source